Benzathine Penicillin G in the Control of Gonorrhoea

Benzathine penicillin G in the control of gonorrhea.

SERUM PENICILLIN LEVEL A FTER INTRAMUSCULA R INJECTION OF 1,200,000 UNITS OF BENZATHINE PENICILLIN G IN CHILDREN WITH RHEUMATIC FEVER

The most accepted method of secondary prophylaxis in rheumatic fever (RF) has been an injection of 1,200,000 units of benzathine penicillin G (BPG) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. The WHO recommended BPG injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of on...

A single dose of benzathine penicillin G is as effective as multiple doses of benzathine penicillin G for the treatment of HIV-infected persons with early syphilis.

BACKGROUND Treatment guidelines recommend the use of a single dose of benzathine penicillin G (BPG) for treating early syphilis in human immunodeficiency virus (HIV)-infected persons. However, data supporting this recommendation are limited. We examined the efficacy of single-dose BPG in the US Military HIV Natural History Study. METHODS Subjects were included if they met serologic criteria f...

Factors associated with loss of penicillin G concentrations in serum after intramuscular benzathine penicillin G injection: a meta-analysis.

BACKGROUND An interval of 3-4 weeks between intramuscular injections of 1.2 million units of benzathine penicillin G as prophylaxis against group A streptococcal infection is recommended by health organizations for patients with pediatric rheumatic fever and heart disease. METHODS We reviewed the literature for evidence of the persistence of serum penicillin G during the first 4 weeks after t...

Penicillin resistance in gonorrhoea.

The incidence of gonorrhoea in Great Britain reached its peak in 1946, one year after the second World War had ended. Thereafter it declined sharply and continued to do so until 1955, when for the first time since the war the Annual Report of the Chief Medical Officer of the Ministry of Health (1957) indicated an increase in the number of patients with'gonorrhoea attending the clinics. The rise...